Sermorelin
10mg · 2ml
SKU: sermorelin-10mg
Sermorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH) that stimulates the pituitary gland to produce growth hormone in a natural pulsatile pattern. It supports downstream IGF-1 production for tissue repair, lean muscle maintenance, improved sleep quality, and metabolic optimization while preserving normal hormonal feedback mechanisms.
Product Specifications
Strength
10mg
Volume / Qty
2ml
Form
Lyophilized Powder
Dosing Guide
Recommended Dose
200-300 mcg
Route
Subcutaneous
Frequency
Once nightly
Clinician Access Required
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Sermorelin is available exclusively to verified clinicians under IRB-approved research protocol PPRN-001-2025.
IRB-Approved Research Protocol
PPRN-001-2025 ·IRCM-2025-467
Approved December 3, 2025 · Principal Investigator: Dr. M. Scott Mortensen, MD, MPAS, MLT
Save up to 80% with the 10,000 Growth Bundle
Sermorelin is included in this clinic-tier package. Bundle includes higher volume in weight loss, mitochondrial health, longevity, and tissue repair with 1 free Tirz 15mg + 1 free Reta 15mg as a bonus.
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For Clinicians
Clinical Reference
Pharmacology, safety, monitoring, and dosing reference for Sermorelin. Always individualize based on patient context.
Mechanism of Action
Receptor / Target
GHRH(1-29) analog; pituitary GHRH receptor agonist
Half-Life
~10–20 minutes
Onset of Action
15 minutes for GH pulse; 4–8 weeks for clinical effects
Metabolism
Hepatic proteolysis
Cautions & Contraindications
Contraindicated In
- Active malignancy
- Hypersensitivity to sermorelin
- Pregnancy and lactation
Use Caution With
- Hypothyroidism (treat first; reduces sermorelin efficacy)
- Obesity may blunt GH response
- Concurrent glucocorticoid therapy (suppresses GH axis)
Suggested Labs to Monitor
IGF-1
Baseline / 6 weeksTSH, free T4
Baseline / 12 weeksOptimal thyroid function is required for sermorelin response.
Fasting glucose, HbA1c
Baseline / 12 weeksLab interpretation guidance comes from peer-reviewed literature. Always individualize based on patient context.
Plumb DISCOVER
What Sermorelin targets
Patient goals, biomarkers, and wearable signals this peptide addresses. Powers the future Plumb AI protocol engine.
Patient Goals
Biomarkers Tracked
Wearable Signals
Essential Protocol Packages
Sermorelin is part of 1 clinical protocol
Bundle this peptide with synergistic compounds at clinic-tier pricing.
Clinical Synergy
Frequently stacked with Sermorelin
Peptides commonly combined with Sermorelin for synergistic clinical outcomes.
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